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High levels of cellular damage are associated with impairment of cellular function and cell death. Partitioning the damage into a fraction of cells in the population improves population fitness and survival. We have previously shown that protein aggregates, resulting from misfolded, damaged proteins, fuse with each other leading to damage partitioning during cell division.
Here, using an analytical treatment of aggregate fusion in dividing cells we present analytical expressions for two measures of damage partition: aggregate mass partition asymmetry between two dividing cells and standard deviation of total aggregate mass across the population. The scaling laws obtained demonstrate how damage partition may generally depend on characteristics of the cellular processes, facilitating better understanding of damage segregation in biological cells.
Research news | 2018-11-17
Study reveals deeply contrasting realities for farmers in South Africa
Research news | 2018-11-16
New report projects area of habitat larger than New Zealand could be lost to urbanization over next 20 years
Research news | 2018-11-15
The fifth in a series of seven "deep dives" looking into the connections between resilience and development
Research news | 2018-11-13
First assessment of planetary boundaries for antibiotic and pesticide resistance shows several are already crossed
Educational news | 2018-11-13
Centre partners with other insitutions at Stockholm University to host a PhD/postdoc course in global and environmental governace
Research news | 2018-11-09
The perception of cognition and other related terms easily get misunderstood in scientific processes, leading to frustration, communication breakdown and a collaboration impasse