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High levels of cellular damage are associated with impairment of cellular function and cell death. Partitioning the damage into a fraction of cells in the population improves population fitness and survival. We have previously shown that protein aggregates, resulting from misfolded, damaged proteins, fuse with each other leading to damage partitioning during cell division.
Here, using an analytical treatment of aggregate fusion in dividing cells we present analytical expressions for two measures of damage partition: aggregate mass partition asymmetry between two dividing cells and standard deviation of total aggregate mass across the population. The scaling laws obtained demonstrate how damage partition may generally depend on characteristics of the cellular processes, facilitating better understanding of damage segregation in biological cells.
Research news | 2018-08-14
New index reveals how climate risks are reinforced by global connectivity, leaving no country shielded from impact
General news | 2018-08-14
Event, Tuesday 11 September 2018 in partnership with ICF and the UN Climate Resilience Initiative A2R. A Global Climate Action Summit affiliate event
Research news | 2018-08-13
New analysis reveals connections between tax havens and resource degradation in both the Amazon rainforest and global fisheries
Research news | 2018-08-06
Keeping global warming to within 1.5-2°C may be more difficult than previously assessed
Research news | 2018-07-10
The World in 2050 initiative launches new report outlining synergies and benefits that render the goals achievable
Research news | 2018-06-27
Overfishing, fractured international relationships and political conflicts loom as fish migrate more unpredictably because of climate change. Here is how to deal with it